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HERDIN Record #: PCHRD071508020752 Submitted: 14 July 2008

Role of statins in improving leg functioning in patients with peripheral arterial disease: A meta analysis .

Leahdette O. Padua

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Background: Recent studies has advocated lipid-lowering with statins in patients with peripheral arterial disease (PAD), largely because of the data from clinical trials in coronary artery disease demonstrating reduction of cardiovascular events. The role of statins in patients with PAD, with respect to reduction of cardiovascular events, has been alluded in major lipid trials. However, its definite role in peripheral arterial disease, particularly in improving leg functioning is still to be attested.

Objectives: To determine the effectiveness of statins in improving leg functioning and ankle brachial indices as well as reducing cardiovascular events among patients with PAD.

Data Source: Medline, Pubmed, Grateful med, Science Direct, and Cochrane controlled Trials Registry

Study Selection: Randomized Controlled Studies on patients with peripheral arterial disease given statins with outcomes on leg functioning and CHD mortality.

Collection and Analysis: Data were entered in the Cochrane Review Manager software. (Review Manager 4.2.5). Weighted Mean, Standard Deviation and Relative Risk were calculated. Heterogeneity was tested using a chi-square test (p<0.05).

Data Synthesis: Statin usage tends to improve ABI among PAD patients. (WMD: -0.02 Cl -0.02 to -0.01), maximum walking time (SMD: 41.75 Cl 37.9, 45.58) and pain-free walking time at 6 months (WMD: 86.68 Cl 71.15, 102.2) and end of study (WMD: 44.54 Cl 41.54, 47.54). Also, statin use can provide protection against coronary heart disease mortality. (RR: 0.58 Cl 0.18, 1.87). Heterogeneity is seen in data for CHD mortality, changes in mean walking time and ABI.

Conclusion: There is a trend showing improvement in leg functioning as attested by gain in pain-free walking time, maximal walking time, and ankle brachial indices. Likewise, statin use tends to have a protective effect in reducing CHD mortality among patients with PAD. (Author)

Publication Type
Publication Sub Type
Review Articles/Metaanalysis
Philippine Heart Center Journal
Publication Date
April-June 2006


ÃÆ'Æ'Æ’ÃÆ'†â€™ÃÆ'Æ'â€Ã...¡ÃÆ'‚¢ÃÆ'Æ'Æ’ÃÆ'¢â‚¬Ã...¡ÃÆ'Æ'¢ÃÆ'¢â‚¬Ã...¡ÃÆ'‚¬ÃÆ'Æ'Æ’ÃÆ'¢â‚¬Ã...¡ÃÆ'Æ'â€Ã...¡ÃÆ'‚¢ To determine the effect of statins in improving walking performance among patients with peripheral arterial disease (PAD).
ÃÆ'Æ'Æ’ÃÆ'†â€™ÃÆ'Æ'â€Ã...¡ÃÆ'‚¢ÃÆ'Æ'Æ’ÃÆ'¢â‚¬Ã...¡ÃÆ'Æ'¢ÃÆ'¢â‚¬Ã...¡ÃÆ'‚¬ÃÆ'Æ'Æ’ÃÆ'¢â‚¬Ã...¡ÃÆ'Æ'â€Ã...¡ÃÆ'‚¢ To ascertain if there is a change in the ankle-brachial indices among patients treated with statins as compared to placebo.
ÃÆ'Æ'Æ’ÃÆ'†â€™ÃÆ'Æ'â€Ã...¡ÃÆ'‚¢ÃÆ'Æ'Æ’ÃÆ'¢â‚¬Ã...¡ÃÆ'Æ'¢ÃÆ'¢â‚¬Ã...¡ÃÆ'‚¬ÃÆ'Æ'Æ’ÃÆ'¢â‚¬Ã...¡ÃÆ'Æ'â€Ã...¡ÃÆ'‚¢ To determine if statins can contribute to reduction of cardiovascular mortality among patients with PAD.

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