Report an error   

HERDIN Record #: PCHRDPC011194 Submitted: 16 May 2007 Modified: 06 April 2013

Left Ventricular diastolic filling doppler indices is a useful adjunct in the interpretation of dobutamine stress echocardiogram.

Grace Casaclang ,
Louwe Go ,
Marietta Crisostomo ,
Gregorio Rogelio,
Mary Ann Lao M,
Homobono Calleja

See More

BACKGROUND: In coronary occlusion or heart failure, abnormal relaxation of the left ventricle is the earliest manifestation
OBJECTIVE: To measure the Doppler derived diastolic indices from baseline to peak dose dobutamine and compare patients with normal (Group I) and abnormal (Group II) wall motion
DESIGN: Case control study of patients who undergo DSE
METHODS: Doppler signals of transmitral blood flow were obtained at baseline and peak dobutamine stress
The following were measured:
Peak early filling velocity E - peak early left ventricular filling velocity (cm/s)
Peak atrial filling velocity A -- velocity of atrial contraction (cm/s)
Peak early to atrial velocity ratio (E/A) - relative contribution of early and late ventricular filling
E acceleration time - rate of increase of E velocity stet (m/s2)
E decceleration time - rate of stet of velocity following E velocity (m/s2)
Total diastolic VTI - velocity time integral (cm)
Isovolumic relaxation time (IVRT) - time from aortic valve closure to mitral valve opening (ms)
Corresponding heart rate - heart rate at time Doppler indices were obtained during baseline and peak dose dobutamine
RESULTS: Patients with normal wall motion and contractility have increased E and A velocities, faster E deceleration time and E acceleration time. The E/A ratio and VTI are unchanged. The IVRT is decreased. Patients with segmental wall motion abnormality have decreased E velocity, unchanged E deceleration time. The E acceleration time may be unchanged. The A velocity is increased. The E/A ratio and IVRT are reduced. The TI is unchanged antihypertensive was doubled.

Publication Type
Publication Sub Type
Journal Article, Original
Philippine Journal of Cardiology
Publication Date
July-September 1999
LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library Box No. 44 Fulltext Print Format
1. Sholnick, David , Segar, Douglas . "Asessment of diatolic function with echocardiography" ACC Current Journal Review , 47-49, March 1997-April 1997
2. Nishimura, R , Tajik, Jamil . "Evaluation of diastolic filling of left ventricular in health and disease: dopper echocardiographic is the clinicians Rosetta Stone" JACC 30, 8-18, 1997
3. Labovitz, Lewen M. "Evaluation of left ventricular systolic and diastolic dysfunction during transient myocardial ischemia produced by angioplasty" JACC 10, 748-55, 1987
4. Go, L . "Evaluation of left ventricular diastolic fucntion by doppler echocardiography " Phil Journal of Cardiovascular Medicine 12, 36-37, 1999
5. El-Said, E , Roelandt, J . "Abnormal left ventricular early diastolic Filling during dobutamine stress doppler echocardiography is a sensitive indicator of significant coronary artery disease" Eur Heart J 24, 1618-24, 1997
6. El-Said, ESM , Fioretti, PM , Roelandt, JRTC . "Dobutamine stress doppler echocardiography bedore and after coronary angioplasty" Eur Heart J 14, 1011-21, 1993
7. Voutilainen, S , Kupari, M . "Factors influencing doppler indexes of left ventricular filling in healthy persons" Am J Cardiol 68, 653-659, 1991
8. Harrison, M , Clifton, D . "Effect of heart rate on left ventricular diastolic transmitral flow velocity patterns assessed by doppler echocardiography in normal subjects" Am J Cardiol 67, 622-627, 1991
9. Masuyama, T , Masaaki, MD . "Abnormal coronary flow dynamics at rest and during tachycardia associated with impaired left ventricular relaxation in humans: implications for tachycardia induced ischemia" JACC 24(7): 1625-32, December 1994

Copyright © One Window Project 2020. All rights reserved.