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HERDIN Record #: NCR-PHA-19012513524377 Submitted: 25 January 2019 Modified: 25 January 2019

The effect of trimetazidine on the left atrial volume index in patients with chronic stable angina a randomized, controlled trial.

Abegeil S.  Diaz-Vinluan,
Raul D. Jara

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BACKGROUND AND OBJECTIVES: Diastolic dysfunction, which can be reflected in the left atrial volume index (LAVI), is present in patients with  chronic stable angina (CSA). This prospective, randomized, double-blind study aimed to determine the effect of the anti-anginal medication, trimetazidine, on the LAVI of patients with CSA.

METHODS: Patients were randomized to receive either trimetazidine 35 mg twice daily or placebo for six months. LAVI, isovolumic relaxation time (IVRT), deceleration time (DT), ejection fraction (EF) and mitral E/A were measured by two-dimensional echocardiography with Doppler (2DED) at baseline and after six months.

RESULTS: Forty patients were included but only 36 had a repeat 2DED after 6 months. The mean LAVI of trimetazidinetreated patients was reduced from 27.06 mL/m2 to 24.06 mL/m2 (p=0.153), and increased from 26.32 mL/m2 to 32.72 mL/m2 in the placebo group (p=0.002). The six-month LAVI in the trimetazidine group (24.06 mL/ m2) also significantly differed from the placebo group (32.72 mL/m2; p=0.017). Changes in LVEF, IVRT and DT tended to favor improvement following trimetazidine treatment, but did not reach statistical significance. E/A on mitral inflow increased from 1.04 to 1.17 in trimetazidine-treated patients (p=0.092), and from 0.99 to 1.49 in placebo-treated patients (p=0.000).


Publication Type
Publication Sub Type
Journal Article, Original
Philippine Journal of Cardiology
Publication Date
July 2010-June 2011
LocationLocation CodeAvailable FormatAvailability
Philippine Heart Association Fulltext pdf (Download)

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