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HERDIN Record #: NCR-RITM-12080213492093 Submitted: 02 August 2012 Modified: 28 May 2013

Association of increased platelet-associated immunoglobulins with thrombocytopenia and the severity of disease on secondary dengue virus infections

A. Kumatori,
K. Moji,
M. Saito,
K. Oishi,
S. Inoue,
K. Morita,
A.M. P. Robles,
R. R. Matias,
F. F. Natividad,
M.T. P. Alera,
M. T. Alonzo,
Corazon C. Buerano,
E. M. Dimaano

Severe thrombocytopenia and increased vascular permeability are two major characteristics of dengue hemorrhagic fever (DHF). To develop a better understanding of the roles of platelet-associated IgG (PAIgG) and IgM (PAIgM) inducing thrombocytopenia and its severity of disease in patients with secondary dengue virus infection, the IgM levels and disease severity as well as thrombocytopenia was examined in 78 patients with acute phase secondary infection on a prospective hospital-based study. The decrease in platelet count during the acute phase recovered significantly during the convalescent phase. In contrast, the increased levels of PAIgG or PAIgM that occurred during the acute phase of these patients decrease significantly during the convalescent phase.An inverse correlation between platelet count and PAIgG or PAIgM levels was found in these patients. Anti-dengue virus IgG and IgM activity was found in platelet eluates from 10 patients in an acute phase of secondary infection. Increased levels of PAIgG or PAIGM were significantly higher in DHF than those in dengue fever (DF). An Increases level of PAIgM was associated independently worth the development of DHF, representing a possible predictor of DHF with a specificity. Our present data suggest that platelet-associated immunoglobulins involving antidengue virus activity play a pivotal role in the induction of thrombocytopenia and the severity of the disease in secondary dengue virus infections

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Publication Sub Type
Journal Article, Original
St. Luke's Journal of Medicine
Publication Date
January-June 2010

Publication Type
Publication Sub Type
Journal Article, Original
Clin Exp Immunol
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